Exploring Genetics and Epigenetics with DNA
DNA stands for Deoxyribonucleic Acid (DNA) and is the molecule that carries genetic information passed down through generations. Every person’s DNA is unique, which makes it possible to trace ancestry, as well as diagnose and treat certain hereditary conditions. It also has an epigenetic component which can be activated or deactivated by environmental factors such as nutrition and lifestyle choices. Below we explore how DNA works, as well as two of the most common mutations – MTHFR C677T and MTHFR A1298C.
How DNA Works
DNA is a double-stranded molecule made up of four nitrogenous bases: adenine (A), thymine (T), guanine (G), and cytosine (C). These nitrogenous bases form base pairs between strands, with A pairing with T, and G pairing with C. These base pairs make up genes that provide instructions for the body’s growth and development.
MTHFR C677T & A1298C Mutations
Mutations occur when changes are made to these base pairs or when one base pair replaces another. Two of the most commonly studied mutations are MTHFR C677T and MTHFR A1298C. The MTHFR gene is responsible for producing an enzyme called methylenetetrahydrofolate reductase (MTHFR) which is important for processing folate in the body. People who have either of these mutations may have difficulty processing folate, leading to health issues such as depression, heart disease, stroke, miscarriage, birth defects, etc.
It’s important to note that not everyone who has these mutations will develop health problems; they may just need to take extra precautions or make dietary changes in order to ensure their bodies get enough folate. It is important to remember when additional folate in way of supplementation is added to a diet magnesium and additional B12 are almost always needed. Additionally, many people may not even know they have either of these mutations until they’re tested.
In summary, DNA is a double-stranded molecule made up of four nitrogenous bases that provide instructions for our bodies’ growth and development. Mutations can occur when changes are made to these base pairs or when one base pair replaces another; two common examples are MTHFR C677T and MTHFR A1298C mutations which can lead to difficulties processing folate in the body if present but do not always cause health issues if properly managed by making dietary adjustments or taking necessary precautions. Understanding DNA can help you uncover any underlying genetic predispositions you may have so that you can make informed decisions about your health moving forward!
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