Home Forums MTHFR Support Forum CBS only shows in Ammonia or also in BUN ?

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  • christian.penninck
    Post count: 4

    Hi ,
    I have CBS C699T AG +- Hetero , CBS N212N AG +- Hetero
    As I understood this can cause to much ammonia.
    Unfortunately here in Belgium MD’s are only willing to do ammonia testing if you have a Hepatic problem.
    So I have problems having my ammonia tested.
    My question can give my (BUN) blood urea nitrogen me a clue.
    Should it read high because much ammonia is produced and thus turned into BUN.
    OR can my (BUN) be low-normal bacause the ammonia is not well enough converted to (BUN) because of the SNP’s.
    Thanks for advice.

    Lea (Admin)
    Post count: 296

    Hi Christian,

    Your question has been forwarded for reply. We appreciate your patience awaiting a response.

    Thank you

    Kind Regards

    Post count: 4

    Oeps made a mistake
    I see now CBS N212N says not genotyped.
    But CBS A360A AG hetero.
    Does that change anything??
    rs2851391 CBS A13637G CT +/-
    rs1801181 CBS A360A AG +/-
    rs706209 CBS C*351T AG +/-
    rs4920037 CBS C19150T AG +/-
    rs234706 CBS C699T AG +/-
    rs12613 CBS G*299A CC -/-
    rs706208 CBS T*330C AG +/-
    ? is C699T AG +- an ammonia issue at all or is it only C699T AA ++ ?

    Cynthia Smith
    Post count: 206

    Hi Christian, Ammonia clearing may be an issue, but I would need to know more. What are your B6 levels, ammonia levels, arginine, citrulline?
    CBS SNPS are not the full picture, nor are MTHFR SNPs. Some of us do well in clearing ammonia, despite SNPs in that pathway. Others do not, depending on their ability to produce BH4. You may want to work with a Practitioner to suss out details of the pathways.

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