Age, race, diabetes, hypertension and ABO blood group major genetic factors affecting Factor VIII and are known to associate with inflammation, a condition that increases risk of problems with FVIII and VWF even in people with normal MTHFR SNPs. Examining your SNP report in a comprehensive way one of the tools I use to strategically supplement for support for normal hormonal, adrenalin and cortisol function and for normal blood flow. Eating a Blood group friendly diet is also a strong factor in supporting normal clotting. 23andMe reports only one PAI-1 SNP: rs2227631. I am an Arizona licensed naturopathic physician and also use Chinese herbal medicine to work with patients internationally via Skype. If you haven’t found the help you need please contact me. For more information you can look at http://greenfieldsclinic.co.uk