Raising Awareness, One Doctor At A Time
Sleep, COVID and Nitric Oxide –
Increase Your NOS to Fight Diseases
You endogenously make nitric oxide in your sleep when you sleep with your mouth closed. If you sleep with your mouth open at night, you aren’t doing your cardiovascular system a favor, but there is hope! Breathe right strips and paper tape can help you retrain you to sleep with your mouth shut. If not, then CPAP can help. More about that further down, but first, let’s talk NOS (Nitric Oxide Synthase) 101:
Nitric oxide synthase 3 [endothelial] (NOS3 aka eNOS, Constitutive NOS)
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There are three types of NOS; NOS1 (Nitric oxide synthase 1, neuronal), NOS2 (Nitric oxide synthase, inducible; aka iNOS), NOS3 (Nitric oxide synthase, endothelial; aka eNOS)
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NOS2 enhances the synthesis of pro-inflammatory mediators such as IL6 and IL8
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NOS3 produces nitric oxide (NO) that is implicated in vascular smooth muscle relaxation through a cGMP-mediated signal transduction pathway. NO mediates vascular endothelial growth factor (VEGF)-induced angiogenesis in coronary vessels and promotes blood clotting through the activation of platelets.
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eNOS is primarily responsible for the generation of NO in the vascular endothelium, a monolayer of flat cells lining the interior surface of blood vessels, at the interface between circulating blood in the lumen and the remainder of the vessel wall. NO produced by eNOS in the vascular endothelium plays crucial roles in regulating vascular tone, cellular proliferation, leukocyte adhesion, and platelet aggregation. Therefore, a functional eNOS is essential for a healthy cardiovascular system.
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Catalytic activity:
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2 L-arginine + 3 NADPH + 4 O2 = 2 L-citrulline + 2 nitric oxide + 3 NADP+ + 4 H2O
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Cofactors: Heme, FAD, FMN, 5,6,7,8-tetrahydrobiopterin
Encouraging Nitric Oxide production inhibits the replication cycle of Severe Acute Respiratory symptoms of SARS-CoV-2
“Our results demonstrated that NO specifically inhibits the replication cycle of SARS CoV, most probably during the early steps of infection.”
https://jvi.asm.org/content/79/3/1966
Associated Studies:
https://www.ncbi.nlm.nih.gov/pubmed/16416260
https://www.ncbi.nlm.nih.gov/pubmed/12379270
https://www.ncbi.nlm.nih.gov/pubmed/16585403
I Sleep With My Mouth Open. Now What?
ZQuiet is here to help you or your bed partner stop snoring, sleep better and improve your relationship. They’ve already helped millions of people — and they’re on a mission to help millions more.
The ZQuiet mouthpiece was developed in 2008 in collaboration with dental and medical experts. It was an overnight success. Today, this FDA Cleared-approved mouthpiece has helped more than a million people stop snoring.
Will you be next? Since 2008, they have added even more products to help snorers and bed partners of snorers, including: nasal breathing aids, supportive chin strips, positional therapy aids, and snore cancelling earbuds.
ZQUIET 60 NIGHT BETTER SLEEP GUARANTEE™ with FREE RETURNS
ZQuiet is committed to better sleep for everyone. Enjoy your purchase for a full 60 nights. If you are unsatisfied for ANY reason whatsoever, simply return your purchase within 60 days for a refund or credit (Trial fees are non-refundable). We will even pay to ship it back!
Nasal breathing aid improves airflow to relieve sinus congestion and reduce snoring. Patented flexible wings fit all sizes and gently expand your nasal passage to increase oxygen intake up to 58% to promote healthy, restorative sleep.
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Quiets nighttime breathing & snoring
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Improves overall sleep quality
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Increases workout performance
Sleep8 supports your CPAP, BIPAP, or APAP with quick and easy equipment maintenance.
100% compatible – Think you’re going to need expensive adapters? Not with us. Sleep8 uses a filter bag, so as long as your supplies and accessories fit in the bag, they’re gettin’ clean.
Ready to travel – Cleaning your CPAP while you travel is no problem. Sleep8 is easy to pack and runs on a rechargeable battery. It goes where you go.
Set and forget – Just press start and Sleep8 will handle everything. And when it’s done, Sleep8 will automatically turn itself off.
Millions of Americans suffer from sleep apnea. And in order to sleep, many are prescribed a CPAP machine by their doctor. What they’re not given is an easy way to clean their CPAP supplies and accessories.
That’s why Sleep8 was created, a revolutionary device that gives CPAP users an affordable and effective way to clean their equipment. Sleep 8 knew if they created a device that was quiet, portable, and easy to use, it would encourage daily cleaning. They also wanted to combat a market that is oversaturated with unreliable information and unsafe devices that leak.
A crucial part of our mission is to educate CPAP users and contain the cleaning process. Most people have no idea their equipment can grow mold, cause sinus issues, or make them sick. It’s important to us to give people a universal device that doesn’t need adaptors and can do it all so they can breathe easy.
Are you interested in finding out your NOS polymorphisms?
Over 550+ genes and 1200+ SNP-s awaits you on Sterling’s App
Try it today!
