Raising Awareness, One Doctor At A Time

Nitric oxide synthase 3 [endothelial] (NOS3 aka eNOS, Constitutive NOS)

• There are three types of NOS; NOS1 (Nitric oxide synthase 1, neuronal), NOS2 (Nitric oxide synthase, inducible; aka iNOS), NOS3 (Nitric oxide synthase, endothelial; aka eNOS)
  • NOS2 enhances the synthesis of pro-inflammatory mediators such as IL6 and IL8
• NOS3 produces nitric oxide (NO) that is implicated in vascular smooth muscle relaxation through a cGMP-mediated signal transduction pathway. NO mediates vascular endothelial growth factor (VEGF)-induced angiogenesis in coronary vessels and promotes blood clotting through the activation of platelets.
• eNOS is primarily responsible for the generation of NO in the vascular endothelium, a monolayer of flat cells lining the interior surface of blood vessels, at the interface between circulating blood in the lumen and the remainder of the vessel wall. NO produced by eNOS in the vascular endothelium plays crucial roles in regulating vascular tone, cellular proliferation, leukocyte adhesion, and platelet aggregation. Therefore, a functional eNOS is essential for a healthy cardiovascular system.
• Catalytic activity:
  • 2 L-arginine + 3 NADPH + 4 O2 = 2 L-citrulline + 2 nitric oxide + 3 NADP+ + 4 H2O
• Cofactors: Heme, FAD, FMN, 5,6,7,8-tetrahydrobiopterin

Encouraging Nitric Oxide production inhibits the replication cycle of Severe Acute Respiratory symptoms of SARS-CoV-2
“Our results demonstrated that NO specifically inhibits the replication cycle of SARS CoV, most probably during the early steps of infection.”

https://jvi.asm.org/content/79/3/1966

Associated Studies:
https://www.ncbi.nlm.nih.gov/pubmed/16416260
https://www.ncbi.nlm.nih.gov/pubmed/12379270
https://www.ncbi.nlm.nih.gov/pubmed/16585403
Contributor: Cynthia Smith Nutrigenomicswellness.com
You endogenously make NOS3 at night when sleeping with your mouth closed. If you are not sleeping with your mouth closed and not on CPAP, as long as you do not have nasal obstruction, your doctor can advise you to use breathe right strips and paper tape to train yourself to sleep with your mouth closed again. Butter lettuce, arugula lettuce, spinach, beetroot and celery are loaded with nitric oxide. You also need lysine and arginine for nitric oxide synthase. People quite often take arginine without lysine and they can get in really bad trouble. Talk to your doctor about lysine and arginine and only take when needed because overuse of these amino acids can be hard on the kidneys. Lysine must be taken on an empty stomach.

Millions of Americans suffer from sleep apnea. And in order to sleep, many are prescribed a CPAP machine by their doctor. What they’re not given is an easy way to clean their CPAP supplies and accessories. That’s why Sleep8 was created, a revolutionary device that gives CPAP users an affordable and effective way to clean their equipment. Sleep 8 knew if they created a device that was quiet, portable, and easy to use, it would encourage daily cleaning.
They also wanted to combat a market that is oversaturated with unreliable information and unsafe devices that leak. A crucial part of our mission is to educate CPAP users and contain the cleaning process. Most people have no idea their equipment can grow mold, cause sinus issues, or make them sick. It’s important to us to give people a universal device that doesn’t need adaptors and can do it all so they can breathe easy.

Sleep 8 System

Sleep8 supports your CPAP, BIPAP, or APAP with quick and easy equipment maintenance.

100% compatible – Think you’re going to need expensive adapters? Not with us. Sleep8 uses a filter bag, so as long as your supplies and accessories fit in the bag, they’re gettin’ clean.

Ready to travel – Cleaning your CPAP while you travel is no problem. Sleep8 is easy to pack and runs on a rechargeable battery. It goes where you go.

Set and forget – Just press start and Sleep8 will handle everything. And when it’s done, Sleep8 will automatically turn itself off.

ZQuiet is here to help you or your bed partner stop snoring, sleep better and improve your relationship. They’ve already helped millions of people — and they’re on a mission to help millions more.

The ZQuiet mouthpiece was developed in 2008 in collaboration with dental and medical experts. It was an overnight success. Today, this FDA Cleared-approved mouthpiece has helped more than a million people stop snoring.

Will you be next? Since 2008, they have added even more products to help snorers and bed partners of snorers, including: nasal breathing aids, supportive chin strips, positional therapy aids, and snore cancelling earbuds

Z Quiet 2-Piece Starter Pack 

The ZQuiet 2-Size Starter Pack provides 2 unique mouthpieces designed to treat snoring comfortably and effectively

• ZQuiet Comfort Size #1 Mouthpiece: Advances Jaw +2mm
• ZQuiet Comfort Size #2 Mouthpiece: Advances Jaw +6mm

Protective Storage Case: Protects your ZQuiet and helps maintain the living hinge. Perfect for frequent travelers.

Some customers need just a small advancement, while others require a little more. ZQuiet gives you both mouthpieces to provide you with the most effective treatment with a patented design that provides comfort and flexibility for both men and women.

Z Quiet Breathe Nasal Breathing AID

Nasal breathing aid improves airflow to relieve sinus congestion and reduce snoring. Patented flexible wings fit all sizes and gently expand your nasal passage to increase oxygen intake up to 58% to promote healthy, restorative sleep.

• Quiets nighttime breathing & snoring
• Improves overall sleep quality
• Increases workout performance

ZQuiet Chin-UP Anti-Snoring Supportive Chin Strips

Discreet facial strips that support the chin during sleep to eliminate loud open mouth snoring.

• Easy to apply single-use strips
• Reduces nighttime dry mouth
• Can be worn with CPAP or ZQuiet Mouthpiece

ZQuiet Clean Anti-Bacterial Cleaning Solution

Mint scented cleaning and sanitizing foam works great for any type of dental appliance. Effectively kills 99.99% of germs and bacteria on contact and removes and prevents offensive odors.

• Kills 99.99% of germs and bacteria.
• Cleans in seconds…just pump, scrub and rinse!
• Convenient 1.5 oz. pump bottle
• Persulfate and chlorine-free safe formulation.
• Provides 1 month of cleanings per container.

ZQuiet Ear Plugs

These compact earplugs use specialized noise filters that reduce snoring and other environmental noises by up to 27 decibels so you can sleep, work, or travel in peace and quiet.

• Each set comes with 2 sizes of ear tips for optimum fit
• Soft hypo-allergenic silicone tips minimize pressure on the ear canal.
• Discreet low-profile design is nearly invisible to others
• Easy to insert and include pull tabs for easy removal
• Set also includes a handy cleaning brush and protective storage case.

ZQuiet Premium Storage Case

The ZQuiet Premium Storage Case is specially designed to protect the ZQuiet mouthpiece and prolong the life of the patented living hinge. The case holds a single Comfort 1 or Comfort 2 mouthpiece

What is a Cytokine Storm?

In a nutshell a cytokine storm is an unwelcome reaction in humans that causes their innate immune system to excessively release and excessive amount of proinflammatory signaling molecules called cytokines.

My Labs for Life has a CytoDx profile.  You can find genetics related to cytokine storms on our variant report and our COVID 19 report. 

CytoDx™ Diagnostic Solutions Serum Test Kit (Blood Draw Required)

CytoDx™ Panel (Serum Test)

Most cytokines can be generally characterized as pro-inflammatory or anti-inflammatory, depending on their primary effects on immune responses.

Immune responses are often further characterized by the type of T helper (Th) cell involved.
CytoDx Analytes:

Gut-Immune Connection
It is now widely recognized that the gut – and especially the gut microbiome – plays a critical role in regulating immune function and has been shown to affect circulating cytokines such as IL-6, TNF-alpha, and IL-17.