Raising Awareness, One Doctor At A Time

MTHFR Support Announcements

  • Floxies
  • Oxalates
  • Mushrooms

Could Floxies Be Dealing with an Impaired Glycine Cleavage System?

I was made aware of oxalates a few years back. Susan Owens from http://lowoxalate.info/ contacted me after she had heard I was wanting to reach out to her and learn a little more about oxalic acid and how it impairs sulfation. At first it was as if she was speaking Chinese to me. If this oxalate issue was such a big thing, why did I not know about it earlier? The day she contacted me, everything that I thought I knew about genetics changed.

Since our meeting, I went from obsessing over methylation to learning about this glyoxylate metabolic process which seemed to be impacting methionine synthase. When the glyoxylate metabolic process/glycine cleavage system is not working, the body makes endogenous oxalate, shuts down methionine synthase due to oxidative stress, starts “hogging” up the transport system it shares with sulfation, prevents D3 and carcinogenic estrogens from being sulfated and prevents us from being able to make GcMAF.

My team at MTHFR Support got to work on pulling SNPs out that were on this glyoxylate metabolic process. This is now one of the sections that most chronically ill focus on. We also started working on a section called the pentose phosphate pathway because without this pathway functioning, B6 activity is poor and the glycine cleavage system which is on the glyoxylate metabolic process has poor activity.

What is a floxie? A floxie is someone who has been injured by fluoroquinolones. Fluoroquinolones are a class of antibiotics used for an array of infections but most commonly used for urinary tract infections. When floxies are injured they usually have poor collagen production. This is where the glyoxylate metabolic process/glycine cleavage system is super important. Ascorbic acid is metabolized to oxalate at high doses and when the glyoxylate metabolic process is not working, the body makes endogenous oxalate. Proline cannot be assimilated when this metabolic process is not functioning and lysine is a big player in B6 activity itself.

The three big players in collagen production are vitamin C, lysine and proline. Now we have many doing a low oxalate diet, but what if I told you that there was something out there that could help you bypass a low oxalate diet? There is even a pilot study on the reduction of glycolic, oxalic and glyceric acids showing a significant reduction in not only the metabolites to do with oxalate but yeast, bacterial and fungal markers as well.

Aquanew.com has a product called Watt-Ahh that has shown just this.

Look at the pilot study yourself.

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