Forum Replies Created
Cynthia SmithParticipantMarch 10, 2017 at 2:01 pmPost count: 206Cynthia SmithParticipantMarch 10, 2017 at 12:26 pmPost count: 206
Hi, Homocysteine can be broken down only via the trans-sulfuration pathway which required P5P (via B6) and serine. Make sure you have both on-board. This catabolic route allows the elimination of L-methionine and the toxic metabolite L-homocysteine (PubMed:23981774, PubMed:20506325, PubMed:23974653).
CSB is also structurally heme dependent (a heme sensor protein). “Cystathionine beta-synthase (CBS) is a unique heme-containing enzyme that catalyzes a pyridoxal 5′-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine. Deficiency of CBS leads to homocystinuria, an inherited disease of sulfur metabolism characterized by increased levels of the toxic metabolite homocysteine. Here we present the X-ray crystal structure of a truncated form of the enzyme. CBS shares the same fold with O-acetylserine sulfhydrylase but it contains an additional N-terminal heme binding site. This heme binding motif together with a spatially adjacent oxidoreductase active site motif could explain the regulation of its enzyme activity by redox changes.”Cynthia SmithParticipantMarch 8, 2017 at 6:08 pmPost count: 206
Hi Alli, Some of the most common anesthesia impairs B 12 enzymes (MTR and MTRR) whether SNPs or not. AS he has COMT SNPs, you may want to consider Black Bear Energy spray with hydroxy and adenyl B12. 4-5 squirts before hand and after. Leafy greens could be a good source of folate as could be about 400 mcgs (not mgs) of methyl folate.
NAC addresses glutathione production as one of the three amino acids needed to build (e.g., cysteine, glycine and glutamic acid).
You may want to consider some organic milk thistle tea as well for liver support.Cynthia SmithParticipantFebruary 17, 2017 at 8:03 pmPost count: 206
Hi Jared, First, Cats Claw SLOWS down dopamine and epinephrine BREAKDOWN so one and/or other tends to go too high. If you have COMT V158M ++ SNPs; its not recommended as you will typically run high in dopamine and/o epic, and not low. Neurotransmitters are complicated as receptors are in play as well, especially domaine receptors DRD2. High dopamine down-regulates associated dopamine receptors (swings ensue); kind of like insulin resistance. I suspect that there may be some alcohol abuse in your genetic family tree, so please be careful with sleep hygiene, anything that manipulates dopamine (pot and alcohol). If you find that pot helps, try only CBD for pain. On another note, Weight gain may be associated with fat malabsorption (yes, you read that correctly!) I don’t have enough data to comment on layered approach here, but if you are grazing on carbs to boost serotonin in the evening, then you may be experiencing lack of fat absorption (poor bile and possibly gallbladder symptoms), so your body is “storing” fats from carb conversion for a rainy day.Cynthia SmithParticipantFebruary 14, 2017 at 9:36 pmPost count: 206
You would need to do a Genova Diagnostics NutrEval FMV, and in combo with genetics, a Practitioner could see if trans-sulfuration is blocked. Its difficult to assist you in detail on this forum and piecemeal. Im not taking new clients as I am working off backlog of folks, but if you would like an appointment, you can contact me at firstname.lastname@example.org and I can set up a Consult with you. Where are you located? Cynthia
PS Thyroid measurements that look “normal” are often not from a Functional Medicine perspective. Did you have TPO measured?Cynthia SmithParticipantFebruary 13, 2017 at 9:12 pmPost count: 206
Hi, Im wondering if you may have hyperthyroid issues going on.
Do NOT take additional B6. Instead, work on your mineral cofactors. Im wondering if conversion through CBS is blocked as its a huge user of Vit B6.
Also, because you are taking cabergoline to raise your dopamine, the dopamine may be shunting to nor-eli and then epic. My BBF has same pituitary tumor and takes same med as yourself. She takes alot of Xanax, which I suspect she is doing to “calm” her nerves due to high epi.
Look into taking a non flushing form of niacin and see if you can get some relief. Look at NutrEval results and only take the B vitamins that are showing up red (highly needed). You will know more when you get the results. The NutrEval in combo with genetics are very telling if you work with someone who has knowledge of biochemical pathways.
Use the Black Bear spray in the am only and start with one or two squirts. Again, niacin may be beneficial.Cynthia SmithParticipantFebruary 12, 2017 at 11:17 pmPost count: 206
No methyl anything for you. Its putting you into high catecholamines; specifically high epi. For your B vitamins, you may want to take Starter B (MTHFRproducts.com) and Black Bear energy spray as B12 contribution. You may also want to take naicinimide to slow down methylation. DO you have COMTV158M SNP?Cynthia SmithParticipantFebruary 10, 2017 at 12:07 pmPost count: 206
Not directly, but you will get info on FUT2 and IgA and other SNPs on your Variant Report, that indicate whether you may have GI issues. Here is a link to another test kit to get specific breakdown of your GI micro biome. https://ubiome.com/microbiome-testing
CynthiaCynthia SmithParticipantFebruary 2, 2017 at 9:46 pmPost count: 206
Hi, I understand your confusion however it’s not about synthetic source of Vit B9. Rather, its about the form of Vit B9. Folic acid to useable form requires 5 enzymatic steps to convert it to usable form for methylation. Using 5MTHF skips those enzymatic steps and is the useable form for methyl swap between B9 and B12. Having said that, leafy green are a good source of Vit B9 that can be assimilated and wind its way through the 5 enzymatic steps.
PreNatals with folic acid can actually block the receptors that take up Vit B9 from leafy greens, and the 5 enzymatic processes, where their output does other good things in body. CynthiaCynthia SmithParticipantJanuary 29, 2017 at 1:23 amPost count: 206Cynthia SmithParticipantJanuary 29, 2017 at 1:18 amPost count: 206
Hi, The genes are listed in a Power point presentation on my website pages 81 to 90 ish under GI and Autoimmune at Lifezonewellness.com. Too much to type here. Some folks have SNPs in those 5 genes that breakdown oxalates. If you are susceptible, then take a Mg citrate capsule when you eat high oxalate foods to bind up the oxalates.Cynthia SmithParticipantJanuary 28, 2017 at 11:22 pmPost count: 206
Hi Doyle, (1) There are two primary pathways i Phase II liver detox to clear heavy meals; methylation and glutathione conjugation. G6PD and glutathione connection: – NOTE: G6PD (via the pentose phosphate pathway) is the only way to generate a reduced form of nicotinamide-adenine dinucleotide phosphate (NADPH), a substance that maintains the reduced form of glutathione (which protects against oxidative damage) in cells. If you have G6PS and H6PD SNPs, you may need extra glutathione support. Glutathione require three amino acids as well (glutamic acid, glycine and cysteine), so if HCL issues, you may be low in the required amino acids. (2) There are many reactions tagged as autoimmune that I believe came from injecting foreign proteins as a vaccine bolus. It may be the reason why you reacted to beef. You may want to do a Cyrex Array 10 to determine if beef is still an issue. (3) I am still taking new clients that contact me before Feb 15th. Cynthia email@example.comCynthia SmithParticipantJanuary 10, 2017 at 3:37 pmPost count: 206Cynthia SmithParticipantJanuary 6, 2017 at 1:37 amPost count: 206
Hi, Make sure that you have a source of active Vit B 6 (P5P) to support the CBS C 699T SNP.
If you also have CYP1B1 and COMT V158M SNPs, support estrogen clearing.
So, estrogen clearing requires methylation support, sulfation support and glucuronidation support in Phase II liver detox. You may want to start with Calcium-D-Glucuratea daily, followed by some sort of broccoli seed extract and lastly methylation support last as you have the CBSC699T.
Starter B and Black Bear Energy spray are a good start for B vitamins. You will likely need mineral support as well. Layering in methyl folate is last step, not first.
Organic coffee enemas are gold standard for liver detox and healthy gallbladder bile.
Just my 2 cents.Cynthia SmithParticipantJanuary 6, 2017 at 1:24 amPost count: 206