Synthetic Folic Acid – MTHFR & Pregnancy's Enemy?

[dillonlisa1Participant May 11, 2015 at 4:40 am Post count: 2]

#13729

I am homozygous MTHFR. I have had more than 10 miscarriages.

When I was first diagnosed with MTHFR the fertility doctor put me onto a high dose of synthetic folic acid and vitamin B. I have only just discovered that was the worst thing to do. I needed to be on active folate and active vitamin B.

Within a month of changing to active folate and vit B I became pregnant, and my HCG levels going up nicely. Still work in progress. Fingers crossed.

Why don’t the doctors know about this? I visited 6 fertility specialists who all knew about my MTHFR, all of them had me on synthetic folic acid. Why doesn’t the industry know about this? Boo hoo.

I have started writing a blog about it.

http://recurrentmiscarriage2.blogspot.co.nz/2015/05/mthfr-gene-mutation-and-folic-acid-is.html

[Lea (Admin)Keymaster May 11, 2015 at 5:31 am Post count: 296]

#13734

Hi dillionlisa1,

I have forwarded your post for reply. Your patience in awaiting a response is appreciated.

Lea

[Cynthia SmithParticipant May 11, 2015 at 2:08 pm Post count: 206]

#13772

Its unfortunate that most Prenatals include folic acid. About 25-30% of the population have poor conversion of synthetic folic acid to 5 MTHF, due to genetics that include DHFR, MTHFD1, and MTHFR. There are some excellent Prenatals by Vital Nutrients, ProThera, Seeking Health, Xymogen that do not include folic acid.
Also, if someone has the combo of SHMT1 and MTHFS, folinic acid may be counter indicated. Cynthia

[LeeParticipant September 17, 2015 at 9:45 pm Post count: 2]

#20553

I am so sorry for your losses. It is so terrible to live through this. I am hetero c677T and homo 4G/4G and had 3 misc.s. and all doctors with “highest degrees” keep prescribing me folic acid saying that its nothing to do with it. That is fda approved and very crucial for pregnancy and heterozygous can absorb with one working allele folic acid. But the blood work shows elevated in folic acid but FSH is elevated because of folate and b12 defficiency. But RE says it is the same folic acid and folate. That this record is lab error.

[LeeParticipant September 17, 2015 at 10:06 pm Post count: 2]

#20554

What would you think about manual physical therapy on MTHFR patients? It would be helpfull?

[Lea (Admin)Keymaster September 17, 2015 at 11:50 pm Post count: 296]

#20555

Hello Lee

I have forwarded your post on to one of the practitioners who provides their time here voluntarily. As we are unable to diagnose or treat on this forum as it would be unethical without consultation and knowing your full history any information provided will only be of a general nature. Your patience in awaiting a response is appreciated as it is not always possible for the practitioners to reply immediately.

Please also consider working with a practitioner such as those on the Find a Practitioner listing here http://mthfrsupport.com/find-a-practitioner/ who are experienced in methylation and nutrigenomics. They can assess your situation and provide you with the appropriate support and treatment specific to your individual needs.

Lea

[Cynthia SmithParticipant September 19, 2015 at 12:50 am Post count: 206]

#20589

First of all, MTHFR SNPs are only part of the biochemical picture and pathways. Remember that our DNA encodes enzymes in the pathways that lay foundation for GI health, neurotransmitter health,thyroid health and more. The nutrient cofactors needed for the enzymatic pathways are key as well. 10 miscarriages is huge wrt hormone imbalance/clearing, and folate pathway. If it was me, I would replete all B vitamins, daily. You can contact me off-line at c.smith@lifezonewellness.com if you are interested in kore info. Cynthia

[Cynthia SmithParticipant September 24, 2015 at 9:32 pm Post count: 206]

#20854

For simple explanation, please look at the FIGs in your Variant Report. When you do so, its obvious that to convert synthetic folic acid to usable folate, requires many enzymatic steps via DHFR (2), MTHFD1 (3) and MTHFR and MTR and MTRR. If pregnant then off-shoot steps of SHMT1 and MTHFS become key. There is no refuting our biochemical pathways and needs, despite degrees held by experts. Cynthia

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