MTHFR and Miscarriages (RPL)

[msz1191Participant October 29, 2013 at 7:36 pm Post count: 3]

#2702

I was recently diagnosed as being compound heterozygous (A1298 and C677T) after suffering my second misccariage. My doctor has told me this was not an issue since my homocysteine levels are normal. I was prescribed with a Rx folic and B vitamin compound (Foltx), but do not feel that I will be addressing this issue by taking it based on some articles I have read. I have shown the doctor articles, and have been dismissed each time stating that all studies she is famililar with indicate that MTHFR is not a cause for miscarriages. I am deciding to take matters into my own hands and purchase the supplements OTC. I just bought Thorne prenatal and a bunch of Solgar products and a local health foods store. However, I am so confused how much to take! The Thorne Prenatal contains 1000mcg Folate (500 mcg as Calcium Folate and 500mcg as L-5-Methyltetrahydrofolate, 200 mcg B12 (100 mcg as Adenosycolbalamin and 100 mcg Methylcobalamin, and 10mg B6 (as P-5-P). I also purchased the following Solgar products: 1000mcg Folate, 1000mcb Methylcobalamin, and 50mg P-5-P. I read the articles that stated that too much Methylfolate could product some adverse symptoms and to start slowly. Is the Thorne prenatal enough to start? Or should I add in some of the Solgar products as well? Please help! This is all so confusing to me! I really want to prepare my body to sustain a healthy pregnancy! Hopefully pregnancy #3 will stick!
I also wanted to note that I went through VERY comprehensive testing with a fertility specialist, and nothing was found besides the MTHFR mutations. My hormone levels looked good, anatomy of cervix/fallopian tubes healthy, no other genetic anamolies.

[drmikeParticipant October 30, 2013 at 2:42 pm Post count: 19]

#2705

Hi. There is a link between MTHFR and miscarriage. http://www.ncbi.nlm.nih.gov/pubmed/?term=mthfr+miscarriage

The best thing to do is to get a comprehensive assessment of where you are functionally. Tests for micronutrients, gut function, anemia, inflammation, etc. and a 23 and me to get the complete picture. Then a customized plan ca be created. Hope that helps. – Dr. Mike

[DrTimJParticipant October 30, 2013 at 8:57 pm Post count: 22]

#2718

I agree with Dr. Mike…you want to test all thyroid markers, gut health, inflammation, and sub-clinical infections. BUT the key is working with someone who knows how to interpret the tests b/c most traditional M.D.s and medical practitioners do not understand optimal vs. normal. Let us know if you have other questions.

–Dr. Tim

[msz1191Participant October 31, 2013 at 12:43 pm Post count: 3]

#2723

Thanks for the reply. Is there a way I can see if the fertility doctor has tested me for everything mentioned? My issue is that my fertility doctor has told me I have “unexplained infertility” because all of my tests came back “normal.” I just don’t know where to turn to for help! Do either of you know of a doctor in the Central NJ/Philly area that would perform a comprehensive assessment? I have already spent a ton of money on the fertility doctor only to be told that she basically cannot help me. I really would like to find a specialist/doctor who is familiar with MTHFR and could give me a customized plan.

[drmikeParticipant October 31, 2013 at 4:43 pm Post count: 19]

#2726

The practitioners here on the MTHFR Support site do skype and phone consults. We look at the testing you have already had through a functional lens. We can also guide you through more testing and create specific programs. Hard to find people who do this locally, as there are so few docs who are using this knowledge clinically.
– Hope that helps.

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