Interpreting result for C667T

[mmburke1956Participant December 2, 2016 at 4:25 pm Post count: 1]

#37127

I am new to all this and have read about heterozygous, homozygous, etc. but don’t know what my result from Sterling’s app means. It shows my C677T result as (+/+), highlighted in red. But here is my confusion. It shows the risk allele as A. I am AA. I thought the risk allele would be T (thymine in place of the usual cytosine). I don’t know if I am homozygous for C677T or in the clear. Can anyone shed some light on this for me, please? Thanks.

[Lea (Admin)Keymaster December 3, 2016 at 3:29 am Post count: 296]

#37136

Hi mmburke1956,

The risk allele for MTHFR C677T is A.

Homozygous is AA (+/+) red, meaning there are two copies of the mutation.

Heterozygous is AG (+/-) yellow meaning one copy of the mutation.

No mutation is GG (-/-) green.

Please read the “Strandedness” information in this article from 23andMe which will also provide answers to your enquiry.
https://customercare.23andme.com/hc/en-us/articles/212883677-How-23andMe-Reports-Genotypes#strand.

Kind Regards
Lea

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